---

Education and Training:   [ Top ]

• Concordia College, Moorhead, MN 56560. B.A. in Biology, with a minor in Philosophy. August 1980 to May 1984.
  
  
• North Dakota State University, Fargo, North Dakota 58105. M.S. in Bacteriology. August 1984 to July 1986.
  
  
• Medical College of Virginia/Virginia Commonwealth University, Health Sciences Division. Richmond, Virginia 23298. Ph.D. from the Department of Microbiology and Immunology. August 1986 to December 1990.
  
  
• Postdoctoral Research. University of Virginia, School of Medicine, Department of Microbiology. Charlottesville, Virginia 22908. January 1991 to January 1997. Investigated the regulation of the cobalamin transporter, BtuB in the laboratory of Dr. Robert Kadner.
  
  
• Postdoctoral Research. University of Virginia, School of Medicine, Department of Microbiology. Charlottesville, Virginia 22908. February 1997 to January 2000. Studied the genetic organization of LPS genes in Pseudomonas aeruginosa in the laboratory of Dr. Joanna Goldberg.

---

Extramural Funding:   [ Top ]

• 2 R25 GM 0089-04 (Bauer, Roger) 9/30/03 – 9/30/04
  Bridges to the Future: Baccalaureate Bridge Program
  Role: Faculty participant.
  
  
• 3 S06 GM 063119-02S2 (Kingsford, Laura) 4/1/03 – 12/1/05
  Support for Continuing Research Excellence (SCORE)
  Role: P.I.

---

Courses Taught:   [ Top ]

Since joining the faculty at Ferris State University I have been responsible for the following courses:

BIOL108: Medical Microbiology. This course is an introduction to the microbial world with an emphasis on human microbial disease mechanism and the basis of a protective immune response. The laboratory provides practical experience with fundamental techniques and instrumentation of modern microbiology. This course was designed primarily for students in allied health associate degree programs.

BIOL286: General Microbiology. The class is an introduction to the microbial world including microbial structure, function, metabolism, classification, genetics, control of microbial growth and immunity. The laboratory provides practical experience with fundamental concepts, techniques, and instrumentation of modern microbiology. This course is designed for students in the clinical laboratory science program and is open to other students by permission of the professor.

---

While on the faculty at California State University, Long Beach I was responsible for the following courses:

MICR320: Bacterial Pathogenesis. This was a core course in the Microbiology curriculum concerned with pathogenic bacteria of humans and animals. The primary emphasis was on bacterial ultrastructure, epidemiology,and mechanisms of pathogenesis. We also covered host defense mechanisms, and antibiotic therapy. In the laboratory, we concentrated upon the isolation and identification of microorganisms by morphological and cultural characteristics.

MICR471: Bacterial Physiology. I covered prokaryotic cellular physiology at the molecular level as related to bacterial growth, reproduction, nutrition, metabolism and ecology. A prior background in Biochemistry was a prerequisite.

MICR496: Undergraduate Directed Research. I supervised several undergraduate students each semester. These projects were all set up to address specific portions of the larger problems that we pursued in my lab.

MICR498H: Senior Thesis. Advanced honors students took this as a capstone to their research in my laboratory. They prepared both oral and written presentations of the data that they generated. This was equivalent to a poster or talk for a scientific meeting - which several of my students attended.

BIOL696: Research Methods. This graduate course focused on the development of the ancillary skills related to biological research, from initiation to presentation and publication. Topics included experimental design, computer-aided information retrieval, technical writing, data presentation, computer design of graphics, preparation of figures and slides, photography. The course culminated with formal oral, poster, and written presentations of research in progress.

BIOL220H: Fundamentals of Bioinformatics. An introduction to the scope and use of biological information databases including protein and nucleotide sequences and molecular structure databases as well as literature databases. Basic methods of comparison of DNA and protein sequences including sequence alignment, analysis of 3-D structures, and phylogenetic analysis. Fundamentals of DNA sequencing and genetic survey techniques including genotyping of nuclear and mitochondrial DNA variation.

---

During my post-doctoral research days at the University of Virginia, I was an adjunct professor at Piedmont Virginia Community College in Charlottesville, Virginia. While there, I taught the following courses:

BIO101 Laboratory: Introductory Biology. This was a one-semester course with an emphasis on general biological processes. I developed laboratory modules to explain classification schemes, enzyme activity, DNA structure, mitosis, and Mendelian genetics.

BIO102 Laboratory: Introduction to Plant and Animal Physiology. This was another one-semester laboratory course. I helped to develop modules for explaining basic animal and plant physiology. Most of the semester was occupied differentiating monocot and dicot plants and fetal pig dissection.

NAS185: Introduction to Microbiology. This class was a general survey of microorganisms for nursing majors. I developed lectures and laboratories emphasizing the characteristics and activities of fungi, protozoa, viruses, and bacteria related to health and disease. Extra emphasis was placed upon on the metabolism and genetic processes of the microbes as well as immunological mechanisms of the host.

---

Publications:   [ Top ]

1. Mercado, G., A. L. Nilges, P. Amêzçua, and C. V. Franklund. Cloning, Purification, and Characterization of NeuA from Fusobacterium nucleatum ssp. polymorphum. (In preparation).
   
   
2. Pandak, W.M., P. Bohdan, C. Franklund, D.H. Mallonee, G. Eggertsen, I. Björkhem, Z.R. Vlahcevic, and P.B. Hylemon. Expression of Sterol 12b-Hydroxylase Alters Bile Acid Pool Composition in Primary Rat Hepatocytes and In Vivo. Gastroenterology 120:1801-1809 (2001).
   
   
3. Dean, C.D., C.V. Franklund, J.D. Retief, M.J. Coyne, Jr., K. Hatano, D.J. Evans, G.B. Pier, and J.B. Goldberg. Characterization of the O Antigen Locus from the Serogroup O11 Pseudomonas aeruginosa Strain PA103: Identification of the O Antigen Polymerase Gene. J. Bacteriol. 181: 4275–4284 (1999).
   
   
4. Franklund, C.V., and J.B. Goldberg. Cloning and Characterization of gltX from Pseudomonas aeruginosa PAK. J. Bacteriol. 181:3582-3586 (1999).
   
   
5. Franklund, C.V. and R.J. Kadner. Multiple Transcribed Elements Control Expression of the Escherichia coli btuB Gene. J. Bacteriol. 179:4039-4042 (1997).
   
   
6. Lathrop, J.T., C.V. Franklund and R.J. Kadner. Communication Between Membranes in TonB-Dependent Transport Across the Bacterial Outer Membrane. In W.N. Kohings, H.R. Kaback and J.S. Lolkema (eds). Handbook of Biol. Phys. Vol. 2. Elsevier Press (1996).
   
   
7. Franklund, C.V., S.F. Baron, and P.B. Hylemon. Characterization of the baiH Gene Encoding a Bile Acid-Inducible NADH:Flavin Oxidoreductase from Eubacterium sp. Strain VPI 12708. J. Bacteriol. 175:3002-3012 (1993).
   
   
8. Baron, S.F., C.V. Franklund, and P.B. Hylemon. Cloning, Sequencing, and Expression of the Gene Coding for Bile Acid 7-Hydroxysteroid Dehydrogenase from Eubacterium sp. Strain VPI 12708. J. Bacteriol. 173:4558-4569 (1991).
   
   
9. Hylemon, P.B., P.D. Melone, C.V. Franklund, E. Lund, and I. Björkhem. Mechanism of Intestinal 7-dehydroxylation of Cholic Acid: Evidence that Allo-Deoxycholic Acid is an Inducible Side-Product. J. Lipid Res. 32: 89-96 (1991).
   
   
10. Franklund, C.V., P. de Prada, and P.B. Hylemon. Purification and Characterization of a Microbial, NADP-Dependent Bile Acid 7-Hydroxysteroid Dehydrogenase. J. Biol. Chem. 265: 9842-9849 (1990).
    
    
11. White, W.B., C.V. Franklund, J.P. Coleman, and P.B. Hylemon. Evidence for a Multigene Family Involved in Bile Acid 7-Dehydroxylation in Eubacterium sp. Strain VPI 12708. J. Bacteriol. 170: 4555-4561 (1988).
    
    
12. Franklund, C.V., and T.L. Glass. Glucose Uptake by the Cellulolytic Rumenal Anaerobe Bacteroides succinogenes. J. Bacteriol. 169: 500-506 (1987).
    

---

The Early Years:   [ Top ]

For those of you who have not already figured it out - I am a nerd. This condition began when I was in the fifth grade. A particularly inspiring teacher (Mr. Hofstad) stimulated my interest in science. Of course, I had no real clue as to what scientists actually do. I didn't figure that one out until I got into graduate school. I occupied many cold Midwestern winters nights by playing around in my makeshift chemistry lab in the basement of our house in Plummer, Minnesota. There, I accidently discovered how to produce chloramine gas as well as other less potentially deadly compounds. I also was into model rocketry when I was younger. Though my friends and I used to put warheads in them to liven up the experience. I guess I would probably be in jail if I tried half that stuff today. :-)